Clindamycin 1) Chemical Name: * methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside 2-(dihydrogen phosphate) 2) Drug name and overlord: * The dose name is Cleocin. Clindamycin is manufactured by several different companies which include Teuto, Ranbaxy, and Stiefel. 3) Mechanism of Action: * Clindamycin is employ to treasure austere infections ca intentd by anaerobic bacteria. Clindamycin is withal prescribed to treat malignant infections due to strains of streptococci, pneumococci, and staphylococci. Clindamycin is an anti-parasitic drug that is prescribed to treat toxoplasmosis. Also, ofttimes it is utilise as investigational treatment for active PCP pneumonia. It besides treats respiratory tract infections. If you are allergic to penicillin, or should non use penicillin harmonise to a medical student, then clindamycin should be employ specifically for these patients. Due to a risk o f colitis, according to the warning on the prescription, a doctor should choose different less cyanogenic alternatives if the infection isnt as serious. An example would be erythromycin. To lessen the cherish the sustainability of Cleocin, it should lone(prenominal) be used to bring back or go on infections and fungi that are definitely caused by vulnerable bacteria. 4) set apart or all-encompassing Spectrum: Narrow Spectrum 5) What organisms is this antibiotic for? * Aerobic positive cocci, including: staph aureus, Staphylococcus epidermidis, when tested by in vitro methods close to staphylococcal strains primarily resistant to erythromycin rapidly cause resistance to clindamycin, strep (except Streptococcus faecalis), Pneumococci. * anaerobic gram-negative bacilli, including: genus Bacteroides species (including Bacteroides fragilis mathematical group and Bacteroides melaninogenucus group), Fusobacterium species. * Anaerobic gram-positive non spore forming bacill i, including: Propionibacterium, Eubacterium! , Actinomyces species. Anaerobic and microaerophilic gram-positive cocci, including: Peptococcus species, Peptostreptococcus species, Microaerophilic streptococci. 6) How is it administered? Clindamycin disregard be administered in 3 mixed steps. Also, for the best results, look upon to take the antibiotic on a daily basis. * by word of mouth Take either with a meal or without a meal. Remember that if you are experiencing stomach pains, take with food. Taking it with a full glass of water is also optional. * Vaginal natural covering - demarcation that the cream can only be used in this area. It may cause burning, and above all do non have sexual intercourse while utilize this drug. * peel off Application Not to be interpreted by mouth. Lotion should be agitate prior to application. take pledget from foil and immediately throw away. take proper hygienics and wash hands before and afterward use. Apply only a thin strip of jelly to avoid irritation. Bandages, mak e-up, etc should not be applied until consulting a doctor for advice. 7) Any toxicities, or side effects? Â Â Â Â Â Â Â Â Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting and diarrhea.
generalized around the bend to moderate morbilliform-like (maculopapular) skin rashes, Vesiculobullous rashes, urticaria, have been find during drug therapy. rare instances of erythema muttiforme, some resembling Stevens-Johnson syndrome, and a few cases of anaphylactoid reactions have also been reported. bitterness and abnormalities in liver function tests have been observed during clindamycin therapy. fugitive neutropenia (leukopenia) and eosinophilia have been reported. Clindamycin has been shown to have neuromuscular blo! cking properties that may call down the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Opposition has been corroborate between clindamycin and erythromycin. Do not take these antibiotics at the aforesaid(prenominal) time. References: 1) Retrieved February 22, 2006, from MedlinePlus Drug training net situation: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682399.html#brand-names 2) Retrieved February 22, 2006, from ADAP drugs Web localise: http://www.atdn.org/access/drugs/clin.html 3) Retrieved February 22, 2006, from clindamycin unremarkably used music for HIV & AIDS patients Web situation: http://www.hivdent.org/drugs/clindamycin.htm 4) Retrieved February 22, 2006, from medicament instructions for clindamycin Web site: http://www1.va.gov/visn10/CincyMedSheets/Clindamycin.htm 5) Retrieved February 22, 2006, from Clindamycin Web site: http://www.clindamycin.com/ If you want to get a full essay, enunciate it on our website:
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